Evidence map›Paper›PMID 41586242›Full record

ArticleFrontiers in nutrition2025

Supplementation of zinc-chelating peptides from

Gita Syahputra, Melva Louisa, Nunik Gustini, Dwi Endah Kusumawati, A'liyatur Rosyidah, Masteria Yunovilsa Putra, Heri Ahmad Sukria, Puspita Eka Wuyung, Fadilah Fadilah, Hee Jae Lee

Abstract read
In one paragraph

Article in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Gita SyahputraDepartment of Pharmacy, Faculty of Pharmacy, Universitas Islam Sultan Agung, Semarang, Indonesia.
Melva LouisaDepartment of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia.
Nunik GustiniResearch Center for Vaccine and Drugs, National Research and Innovation Agency, Jakarta, Indonesia.
Dwi Endah KusumawatiDepartment of Pharmacy, Faculty of Pharmacy, Universitas Islam Sultan Agung, Semarang, Indonesia.
A'liyatur RosyidahResearch Center for Vaccine and Drugs, National Research and Innovation Agency, Jakarta, Indonesia.
Masteria Yunovilsa PutraResearch Center for Vaccine and Drugs, National Research and Innovation Agency, Jakarta, Indonesia.
Heri Ahmad SukriaDepartment of Nutrition and Food Technology, Bogor Agricultural University, Bogor, Indonesia.
Puspita Eka WuyungDepartment of Pathology Anatomy, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia.
Fadilah FadilahDepartment of Medical Chemistry, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia.
Hee Jae LeeDepartment of Pharmacology, School of Medicine, Kangwon National University, Chuncheon, Republic of Korea.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Zinc deficiency in children remains a significant health risk, impairing their physical and cognitive maturation. Supplementation with peptide-bound zinc is thought to offer better bioavailability than inorganic zinc salts. Methods: Pregnant Sprague Dawley rats were fed either a standard zinc diet (40 mg of zinc per kg of feed) or a zinc-deficient diet (4 mg of zinc per kg of feed). Twelve rat offspring born on the standard zinc diet were randomly assigned to receive either vehicle only or ZCP 40 mg/kg BW. Twenty-four offspring born from zinc-deficient maternal rats were divided into groups that received vehicle only, ZCP 4 mg/kg BW, ZCP 40 mg/kg BW, or ZnSO Results: ZCP supplementation significantly increased serum and duodenal zinc levels, metallothionein concentration, and mRNA expressions of ZIP2/ZIP4 in zinc-deficient rat offspring compared to untreated zinc-deficient ones. Supplementation with ZCP at 4 mg/kg BW showed superior or equivalent improvements compared with ZnSO Conclusion: Zinc chelating peptides from

Indexed as

metallothioneinzinc deficiencyzinc transporterZIP2ZIP4ZnSO4

Identifiers

PMID41586242
PMCPMC12827153

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.