ArticleFrontiers in nutrition2025
Unveiling bioactive compounds in kola nut seeds: GC-MS identification and computational analysis for anticancer potential.
Article in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Cancer continues to pose a critical global health challenge, with conventional therapies often limited by efficacy and adverse side effects. In search of safer and more effective treatments, medicinal plants offer a treasure trove of bioactive compounds with therapeutic potential. Kola nut ( Methods: This study explores the anticancer potential of kola nut seeds extract by first identifying its chemical constituents through gas chromatography-mass spectrometry (GC-MS), followed by molecular docking of selected compounds against the cancer-associated target PI3Kα. A methanolic extract was fractionated using column chromatography, yielding nine distinct fractions. The first four fractions were analyzed directly by GC-MS, while the remaining five were derivatized (silylated) prior to analysis. Results and discussion: A total of 78 diverse compounds were identified, spanning alkaloids, flavonoids, fatty acids, and carbohydrates. From these, 15 bioactive compounds, including scopolin, picropodophyllin, catechin, yohimbine, squalene, campesterin, epicatechin, stigmasterol,
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.