ArticleFrontiers in nutrition2025
Adjuvant nutritional support for patients with acute-on-chronic liver failure reduce the risk of clinical complications.
Article in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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3 authors.
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Abstract
Background: Acute-on-chronic liver failure (ACLF) patients face high risks of nutritional risk and clinical complications, but whether adjuvant nutritional support reduces adverse complications remains unclear. Methods: This study included 6,097 hospitalized ACLF patients at West China Hospital. The Nutrition Risk Screening (NRS 2002) was used to assess the nutritional risk of the patients. Additional personalized enteral or parenteral nutrition was provided. The Kruskal-Wallis test and chi-square test compared continuous and categorical variables. Multivariate logistic regression analyzed odds ratios (ORs) and 95% confidence intervals (95% CI) for nutritional intervention and adverse outcomes, while the Cox model evaluated all-cause mortality risk. Results: Among participants (median age 53 years, 69.2% male), 52.5% (3,201) had nutritional risk, who were older, had lower body mass index (BMI), longer hospital stays, and higher rates of infection, hepatorenal syndrome, hepatic encephalopathy, coagulation disorders, and mortality ( Conclusion: Over half of liver failure patients have nutritional risk. Adjuvant nutritional support was associated with significantly lower frequencies of clinical complications, especially ascites and SBP, regardless of nutritional risk.
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