Evidence map›Paper›PMID 41586159›Full record

ArticleCurrent clinical microbiology reports2025

Emerging Roles of Modern Lifestyle Factors in Microbiome Stability and Functionality.

Ye Yang, Maria C Hernandez, Siddhi Chitre, Christian Jobin

Abstract read
In one paragraph

Article in Current clinical microbiology reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Ye YangDepartment of Medicine, Division of Gastroenterology, CGRC, University of Florida, 2033 Mowry Rd, Office 462, PO Box 103633, Gainesville, FL 32610, USA.ORCID 0000-0002-7576-3067
Maria C HernandezDepartment of Medicine, Division of Gastroenterology, CGRC, University of Florida, 2033 Mowry Rd, Office 462, PO Box 103633, Gainesville, FL 32610, USA.ORCID 0000-0003-2958-5594
Siddhi ChitreDepartment of Medicine, Division of Gastroenterology, CGRC, University of Florida, 2033 Mowry Rd, Office 462, PO Box 103633, Gainesville, FL 32610, USA.ORCID 0000-0003-2139-3125
Christian JobinDepartment of Medicine, Division of Gastroenterology, CGRC, University of Florida, 2033 Mowry Rd, Office 462, PO Box 103633, Gainesville, FL 32610, USA.ORCID 0000-0002-3733-1001

Funding

Microbiota, Metabolites, and Colon NeoplasiaR01CA252045 · NCI · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI JOBIN, CHRISTIAN, ROSENBERG, DANIEL WILLIAM · 2021 to 2025
$3.1M
Role of bacterial-derived small molecules in immunotherapyR01CA292532 · NCI · UNIVERSITY OF FLORIDA · PI Christian Jobin · 2025 to 2026
$1.1M
NCI NIH HHS R01 CA252045NCI NIH HHS R01 CA292532
6 · The paper itself

Abstract

Purpose of Review: It is now evident that the microorganisms living on and inside the human body modulate a myriad of host responses and activities. Particularly, the intestinal microbiota, which comprises diverse bacteria, fungi, archaea, viruses, and eukaryotic entities, forms a close relationship with the host. This relationship is essential for optimal biological function such as maintaining proper immune homeostasis, host metabolism, and prevention of pathogens colonization. The human gut microbiome is relatively stable after 3 years of age but is subjected to influences from diet, environment and lifestyle factors. This review covers recent findings on how lifestyle factors associated with modern society might affect the microbiome. Recent Findings: Modern lifestyle factors including circadian rhythm disruption, sleep deprivation, exercise and stress impact the gut bacterial community (bacteriome) composition and function. The resultant gut bacteriome changes contribute to host metabolism dysregulation, inflammatory diseases and cancer development associated with these lifestyle factors. Summary: Lifestyle factors influence the gut bacteriome to modulate host health and disease risks. Understanding the mechanistic roles of diverse host-associated microorganisms played in lifestyle factors-associated disease risks holds the promise for developing novel approaches to alleviate the detrimental effects.

Indexed as

Circadian rhythmExerciseMicrobiotaSleep deprivationStress

Identifiers

PMID41586159
PMCPMC12826544

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.