Evidence map›Paper›PMID 41586154›Full record

ArticleJournal of biomedical optics2026

Particle size distribution and concentration of Intralipid

Mona Shahsavari, Martine Kuiper, Mendel Engelaer, Martin Poinsinet de Sivry-Houle, Ton G van Leeuwen, Edwin van der Pol

Abstract read
In one paragraph

Article in Journal of biomedical optics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Mona ShahsavariUniversity of Amsterdam, Amsterdam UMC, Biomedical Engineering & Physics, Amsterdam, The Netherlands.ORCID https://orcid.org/0000-0003-1215-3277
Martine KuiperUniversity of Amsterdam, Amsterdam UMC, Biomedical Engineering & Physics, Amsterdam, The Netherlands.ORCID https://orcid.org/0000-0002-4533-8617
Mendel EngelaerUniversity of Amsterdam, Amsterdam UMC, Biomedical Engineering & Physics, Amsterdam, The Netherlands.ORCID https://orcid.org/0009-0000-3770-6056
Martin Poinsinet de Sivry-HouleUniversity of Amsterdam, Amsterdam UMC, Biomedical Engineering & Physics, Amsterdam, The Netherlands.ORCID https://orcid.org/0000-0002-3637-7673
Ton G van LeeuwenUniversity of Amsterdam, Amsterdam UMC, Biomedical Engineering & Physics, Amsterdam, The Netherlands.ORCID https://orcid.org/0000-0002-5642-1133
Edwin van der PolUniversity of Amsterdam, Amsterdam UMC, Biomedical Engineering & Physics, Amsterdam, The Netherlands.ORCID https://orcid.org/0000-0002-9497-8426

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Significance: Intralipid Aim: We aim to determine the particle size distribution (PSD), concentration, and refractive index (RI) of particles in Intralipid Approach: Cryo-electron microscopy, three different flow cytometers, and microfluidic resistive pulse sensing were used to measure the size distribution and concentration of particles in Intralipid Results: The PSD, obtained from measurements of more than 10 million particles, spanned from 67 nm to over 2000 nm, with concentration decreasing continuously as diameter increased. The particle volume fraction calculated from the PSD deviated by less than 2% from the expected value, confirming the accuracy of the measurements. Optical parameters calculated from the PSD and RIs, including the scattering coefficient, phase function, anisotropy factor, and reduced scattering coefficient, showed good agreement with values reported in the literature. These parameters were also well described by empirical fits ( Conclusions: The accurate measurement of particle size, concentration, and RI of Intralipid

Indexed as

Fat Emulsions, IntravenousPhospholipidsSoybean OilCryoelectron MicroscopyEmulsionsParticle SizePhantoms, ImagingRefractometryEmulsionsFat Emulsions, IntravenousPhospholipidsSoybean Oilsoybean oil, phospholipid emulsionanisotropy factorIntralipid®particle size distributionphase functionrefractive indexscattering coefficient

Identifiers

PMID41586154
PMCPMC12828180

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.