Evidence map›Paper›PMID 41586120›Full record

ArticleJournal of reproduction & infertility

Serum Levels of CCN3 Protein in Iranian Women with Polycystic Ovary Syndrome.

Akram Vatannejad, Fatima Zahraa Fouani, Reza Fadaei, Asma Kheirollahi, Soheila Ansaripour, Maryam Shabani Nashtaei, Nariman Moradi, Hossein Montakhab-Yeganeh, Faezeh Fattahi, Farah Jadidizadeh

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Article in Journal of reproduction & infertility. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Akram VatannejadDepartment of Comparative Biosciences, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran.
Fatima Zahraa FouaniDepartment of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.
Reza FadaeiSleep Disorders Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Asma KheirollahiDepartment of Comparative Biosciences, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran.
Soheila AnsaripourReproductive Biotechnology Research Center, Avicenna Research Institute, ACECR, Tehran, Iran.
Maryam Shabani NashtaeiDepartment of Infertility, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Nariman MoradiLiver and Digestive Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran.
Hossein Montakhab-YeganehDepartment of Biochemistry, Faculty of Medicine, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.
Faezeh FattahiEmergency Department, Shahid Fayazbakhsh Hospital, Tehran, Iran.
Farah JadidizadehDepartment of Comparative Biosciences, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Polycystic ovary syndrome (PCOS) is a heterogeneous condition that encompasses several cardiometabolic and endocrinological disorders. Studies have shown that its pathogenesis aligns with several underlying mechanisms associated with recurrent pregnancy loss (RPL). Cellular communication network (CCN)-3 protein is a well-studied adipokine involved in tumorigenesis, organogenesis, inflammation, fibrosis, and glucose metabolism. The purpose of the current study was to determine the association of CCN3 levels with a number of parameters involved in PCOS pathogenesis. Methods: This is a case-control study including 120 PCOS patients (60 cases with RPL; PCOS-RPL and 60 cases with infertility; PCOS-Inf and 60 healthy controls). Circulating levels of homocysteine and high-sensitivity C-reactive protein (hs-CRP), homocysteine, and CCN3 were measured using ELISA kits. Results: Circulating levels of CCN3 were significantly elevated in PCOS-RPL and PCOS-Inf subgroups when compared to the control group (7.61±3.03 and 6.85±2.54 Conclusion: According the results of this study CCN3 may be involved in the pathogenesis of PCOS. However, future studies are needed to evaluate the possibility of utilizing CCN3 in the diagnosis and treatment of the disease.

Indexed as

AbortionCCN3C-reactive proteinHomocysteineMetabolic syndromeNephroblastoma overexpressed proteinPolycystic ovary syndrome

Identifiers

PMID41586120
PMCPMC12828057

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.