Evidence map›Paper›PMID 41585991›Full record

ArticleEnvironmental science and ecotechnology2026

Nanoplastics amplify 6PPD ocular toxicity in zebrafish.

Jian Lin, Dongliang Pan, Xingxing Chen, Minyan Xu, Yangfan Zhu, Yi Zheng, Yang Song, Jiangfei Chen

Abstract read
In one paragraph

Article in Environmental science and ecotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jian LinThe Second Affiliated Hospital of Wenzhou Medical University, Wenzhou Municipal Key Laboratory of Neurodevelopmental Pathology and Physiology, Wenzhou, 325035, China.
Dongliang PanThe Second Affiliated Hospital of Wenzhou Medical University, Wenzhou Municipal Key Laboratory of Neurodevelopmental Pathology and Physiology, Wenzhou, 325035, China.
Xingxing ChenZhejiang Mariculture Research Institute, Zhejiang Key Laboratory of Coastal Biological Germplasm Resources Conservation and Utilization, Wenzhou, 325000, China.
Minyan XuSchool of Public Health, Wenzhou Medical University, Wenzhou, 325035, China.
Yangfan ZhuSchool of Public Health, Wenzhou Medical University, Wenzhou, 325035, China.
Yi ZhengThe Second Affiliated Hospital of Wenzhou Medical University, Wenzhou Municipal Key Laboratory of Neurodevelopmental Pathology and Physiology, Wenzhou, 325035, China.
Yang SongState Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, 100085, China.
Jiangfei ChenThe Second Affiliated Hospital of Wenzhou Medical University, Wenzhou Municipal Key Laboratory of Neurodevelopmental Pathology and Physiology, Wenzhou, 325035, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nanoplastics and tire-derived chemicals are ubiquitous co-pollutants in aquatic environments, originating from road runoff and posing potential risks to vertebrate development through enhanced bioavailability and synergistic toxicity. Polystyrene nanoplastics (PS) can adsorb hydrophobic organics like the antioxidant N-(1,3-dimethylbutyl)-N'-phenyl-p-phenylenediamine (6PPD), acting as vectors that increase tissue accumulation and exacerbate oxidative stress, while 6PPD alone disrupts mitochondrial function and induces sublethal effects in exposed organisms. The vertebrate eye, with its direct environmental exposure and sensitive neural structures, is particularly vulnerable, yet the combined impact of PS and 6PPD on visual morphogenesis remains underexplored. Here we show that co-exposure to environmentally relevant concentrations of PS (1 mg L

Indexed as

6PPDCo-exposureNanoplasticsOcular toxicityZebrafish

Identifiers

PMID41585991
PMCPMC12830295

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.