Evidence map›Paper›PMID 41585961›Full record

ArticleNational journal of maxillofacial surgery

Evaluation of bone maturation following application of treated tooth bio-graft in bone defects: Experimental animal study.

Mena F Abd-Allah, Abeer S Gawish, Abd El Rahman O El Mekkawi, Nouralhouda F Abd-Allah, Nadia A Radi, Fatma Mahmoud Abdel-Rahman, Abdullah Saeidi, Shadia A Elsayed, Inas M Mohamed

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Article in National journal of maxillofacial surgery. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Mena F Abd-AllahDepartment of Oral Biology, Al-Azhar University, Cairo, Egypt.
Abeer S GawishDean of Graduate Studies Sinai University ELARISH and Department of Oral Medicine, Periodontology Oral Diagnosis and Radiology, Al-Azhar University, Cairo, Egypt.
Abd El Rahman O El MekkawiDepartment of Endodontics, Faculty of Dentistry, Sini University, Egypt.
Nouralhouda F Abd-AllahDepartment of Pedodontics and Oral Health, Al-Azhar University, Cairo, Egypt.
Nadia A RadiDepartment of Oral and Dental Pathology, Al-Azhar University, Cairo, Egypt.
Fatma Mahmoud Abdel-RahmanDepartment of Dental Biomaterials Department, Faculty of Dental Medicine for Girls, Al-Azhar University, Cairo, Egypt.
Abdullah SaeidiDepartment of Oral and Maxillofacial Diagnostic Sciences, Taibah University, College of Dentistry, Saudi Arabia.
Shadia A ElsayedDepartment of Oral Biology, Al-Azhar University, Cairo, Egypt.
Inas M MohamedDepartment of Dental Biomaterials, Dental Biomaterials Department, Faculty of Dental Medicine for Girls, Al-Azhar University, Cairo, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: The aim of the present study was to evaluate bone maturation in a standardized bone defect model after the application of a treated tooth graft (TTG) formed from demineralized dentin loaded with statin. Materials and Methods: In this study, 30 adult male rabbits (weight 2 kg to 2.5 kg) were used, and they were divided equally into two groups: control and TTG groups. In each rabbit, two standardized round bone defects were created (one in each tibia), where the defects were left without grafting in the control group and were packed with TTG slices in the study group. TTG is formed of demineralized dentin matrix slices loaded with statin. The fifteen rabbits in each group were separated into three subgroups based on postoperative evaluation intervals (2, 4, and 6 weeks). The animals were euthanized at 2, 4 and 6 weeks postoperatively, and half of the bone specimens were processed for histological examination using Masson's trichrome special stain, while the other half was prepared for analysis using energy-dispersive X-ray spectroscopy (EDX). Results: The histomorphometry analysis results showed a significantly greater mean of red-staining bone matrix area for the TTG group, suggesting that the new bone matrix was more mature. Enhanced collagen maturation appeared histologically coupled with an increase in mineral contents, as indicated by SEM-EDX results, where the concentrations of Ca and P increased significantly with time in TTG group ( Conclusion: TTG group consistently showed higher levels of Ca and P and lower C/(Ca+P) ratios compared to the Control group. TTG was able to fasten the maturation of bone formation during bone defect healing.

Indexed as

Bone repairmaturationstatintreated tooth graft

Identifiers

PMID41585961
PMCPMC12829640

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