Evidence map›Paper›PMID 41585910›Full record

ReviewStroke (Hoboken, N.J.)2023

Current Indications for Intraarterial Chemotherapy in Neurointerventional Surgery.

Bryan T Mott, Ankitha Iyer, Eleanor Smith, Kyle Fargen, Patrick Brown, Stacey Quintero Wolfe

Abstract readReview
In one paragraph

Review in Stroke (Hoboken, N.J.), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. In search of real-world cerebroprotection: An institutional perspective and review of the literature.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Bryan T MottDepartment of Neurological Surgery Wake Forest School of Medicine Winston-Salem NC.
Ankitha IyerDepartment of Neurological Surgery Wake Forest School of Medicine Winston-Salem NC.
Eleanor SmithDepartment of Neurological Surgery Wake Forest School of Medicine Winston-Salem NC.
Kyle FargenDepartment of Neurological Surgery Wake Forest School of Medicine Winston-Salem NC.
Patrick BrownDepartment of Neurological Surgery Wake Forest School of Medicine Winston-Salem NC.
Stacey Quintero WolfeDepartment of Neurological Surgery Wake Forest School of Medicine Winston-Salem NC.ORCID https://orcid.org/0000-0001-7603-2728

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: In pursuit of a cure for cancer, it is imperative to utilize every tool, resource, and strategy. Included under this umbrella is the optimization of drug delivery. Broadly speaking, anti-cancer treatment has been perpetually hindered by off-target activity, systemic toxicity, and other adverse reactions. Intraarterial (IA) delivery of therapeutics is an approach that has garnered increased attention in recent years. This approach can deliver drug directly to the desired site with the potential to minimize systemic toxicity. Methods: In this review, we briefly cover existing IA indications for peripheral solid tumors as a base from which we can learn, followed by trials and procedural considerations of IA drug delivery for neck, head, and central nervous system tumors. Results: While the bulk of IA research and clinical trials have focused on drug delivery outside of the central nervous system, there have been recent encouraging results in IA tumor treatment within the neurointerventional arena, such as head and neck tumors, retinoblastoma, glioblastoma multiforme, and central nervous system lymphoma. Conclusion: This review highlights the need for increased clinical research on IA chemotherapeutic delivery as a multi-disciplinary approach involving neurointerventional surgeons.

Indexed as

CNS lymphomaglioblastoma multiformehead and neck squamous cell cancerintraarterial chemotherapyneuroendovascularneurointerventionalretinoblastoma

Identifiers

PMID41585910
PMCPMC12778610

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.