Evidence map›Paper›PMID 41585908›Full record

ArticleStroke (Hoboken, N.J.)2023

Morphological Characteristics of Ruptured Brain Aneurysms: A Systematic Literature Review and Meta-Analysis.

Sebastian Sanchez, Meredith Hickerson, Rishi R Patel, Dana Ghazaleh, Ranita Tarchand, Geeta S Paranjape, Holly Pope, Santiago Ortega-Gutierrez, John M Pederson, David Hasan and 2 more

Abstract read
In one paragraph

Article in Stroke (Hoboken, N.J.), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Morphological characteristics of brain aneurysms among age groups.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2026
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  3. Observational
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  10. Computational fluid dynamics and shape analysis enhance aneurysm rupture risk stratification.International journal of computer assisted radiology and surgery · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Sebastian SanchezDepartment of Neurology University of Iowa Hospitals and Clinics Iowa City IA.
Meredith HickersonDepartment of Neurology University of Iowa Hospitals and Clinics Iowa City IA.
Rishi R PatelDepartment of Neurology University of Iowa Hospitals and Clinics Iowa City IA.
Dana GhazalehDepartment of Neurology University of Iowa Hospitals and Clinics Iowa City IA.
Ranita TarchandNested Knowledge, Inc St Paul MN.
Geeta S ParanjapeNested Knowledge, Inc St Paul MN.
Holly PopeNested Knowledge, Inc St Paul MN.
Santiago Ortega-GutierrezDepartment of Neurology University of Iowa Hospitals and Clinics Iowa City IA.
John M PedersonDepartment of Neurology University of Iowa Hospitals and Clinics Iowa City IA.
David HasanDepartment of Neurosurgery Duke University Durham NC.
Madhavan L RaghavanRoy J. Carver Department of Biomedical Engineering University of Iowa Iowa City IA.
Edgar A SamaniegoDepartment of Neurology University of Iowa Hospitals and Clinics Iowa City IA.ORCID https://orcid.org/0000-0003-2764-2268

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: It is unclear what morphological features of brain aneurysms are better at predicting risk of rupture. We conducted a meta-analysis to analyze the best morphological determinants of rupture status. Methods: The Nested Knowledge platform was used to perform a search of articles reporting on aneurysm size, aspect ratio (AR), size ratio (SR), ellipticity index, nonsphericity index, and undulation index. The mean differences between ruptured and unruptured aneurysms were used to calculate effect sizes. Results: A total of 63 studies with 13 025 aneurysms were included: 6966 ruptured aneurysms and 6059 unruptured aneurysms. Ruptured aneurysms had a larger size ( Conclusions: Size is not significantly different between ruptured and unruptured aneurysms located in the anterior cerebral artery, anterior communicating artery, and basilar artery. SR is significantly different between ruptured and unruptured aneurysms in all locations. A mean AR of 1.5 and SR of 2.3 are the thresholds associated with ruptured aneurysm status.

Indexed as

Aneurysmaspect ratioellipticity indexmeta‐analysisnonsphericity indexsize ratioundulation index

Identifiers

PMID41585908
PMCPMC12778629

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.