Trial reportFrontiers in pharmacology2025
Effectiveness of diterpene ginkgolides meglumine injection after endovascular therapy for cardioembolic stroke: a randomized controlled trial.
Trial report in Frontiers in pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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4 authors.
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Abstract
Background: Endovascular interventional therapy is an important treatment method for cardioembolic stroke. Diterpene Ginkgolides Meglumine Injection (DGMI) may serve as an adjunct to endovascular interventional therapy for acute ischemic stroke. Methods: Patients with cardioembolic stroke receiving endovascular treatment were recruited and randomly assigned in a 1:1 ratio to either the DGMI treatment group or the control group. After the procedure, all patients routinely received management of risk factors and standard medication. Patients in the treatment group additionally received DGMI 25 mg diluted in 250 mL normal saline, administered by intravenous drip once daily for 14 consecutive days. NIHSS scores, modified Rankin Scale (mRS) scores, and hematologic parameters were measured, with adverse reactions monitored throughout. Results: A total of 104 patients completed the study. After 14 days of treatment, HCT was significantly lower and PT was significantly higher in the treatment group (( Conclusion: The combination of DGMI with endovascular therapy in patients with cardioembolic stroke is associated with reduced levels of coagulation biomarkers, improved neurological function, and better long-term prognosis, suggesting its potential as a complementary treatment following interventional procedures in clinical practice.
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