ArticleFrontiers in pharmacology2025
Adherence to denosumab therapy and all-cause mortality in dialysis patients with osteoporosis: a retrospective cohort exploratory study.
Article in Frontiers in pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Dialysis patients have a high risk of osteoporosis, leading to increasedfracture and mortality rates. Denosumab is commonly used in thispopulation due to its lack of renal accumulation, but its long-termbenefit depends on sustained adherence. This This exploratory study investigated therelationship between denosumab adherence and all-cause mortality indialysis patients with osteoporosis. Methods: This retrospective case--control study included 1,200 hemodialysis patients. Four hundred deceased patientswere matched 1:3 by age, sex, and follow-up duration to 1,200 survivingcontrols. Adherence to denosumab therapy was calculated, and itsassociation with mortality was assessed using Cox regression analysis. Results: Among 401 denosumab-treated patients, 12 died and 389 survived duringfollow-up. The deceased group was older than survivors (85.0 ± 11.07 vs.75.87 ± 10.24 years, *p* = 0.016). Poor adherence occurred in 50% ofdeceased patients versus 7.5% of survivors (*p* <0.001).Comorbidities, including diabetes, hypertension, rheumatoid arthritis, liver disease, pulmonary disease, and cancer, differed significantlybetween groups. In Cox regression analysis, older age (HR = 1.137, 95%CI = 1.044-1.239) and poor adherence (HR = 0.065, 95% CI = 0.015-0.288) were significantly associated with higher mortality. Conclusion: Good adherence to denosumab therapy was associated with lower all-causemortality risk in dialysis patients withosteoporosis. Improving treatment adherence may enhance survival in this high-risk population. Given the exploratory nature of this study and the limited number of events, these findings require validation in larger cohorts.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.