Evidence map›Paper›PMID 41585869›Full record

ArticleFrontiers in pharmacology2025

Erythrosine-induced hepatic biomarkers and histopathological changes in male rats: protective effects of lycopene and anthocyanin.

Safa H Qahl, Fatimah A Alqahtani, Haleema Al-Nahari, Fawzyah A Alghamdi, Fatimah H Khouja, Amna H Khouja

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Article in Frontiers in pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Safa H QahlDepartment of Biological Sciences, College of Science, University of Jeddah, Jeddah, Saudi Arabia.
Fatimah A AlqahtaniDepartment of Biology, College of Science, University of King Khalid University, Abha, Saudi Arabia.
Haleema Al-NahariDepartment of Biological Sciences, College of Science, University of Jeddah, Jeddah, Saudi Arabia.
Fawzyah A AlghamdiDepartment of Biological Sciences, College of Science, University of Jeddah, Jeddah, Saudi Arabia.
Fatimah H KhoujaKing Saud bin Abdulaziz University for Health Sciences, Jeddah, Saudi Arabia.
Amna H KhoujaKing Saud bin Abdulaziz University for Health Sciences, Jeddah, Saudi Arabia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study aimed to explore and reassess the safety and efficacy of the synthetic food dye erythrosine (ERY) with respect to the hepatic biomarkers and histological changes in male adult rats as well as possibly alleviate the effects of ERY through administration of lycopene (LYC) and anthocyanin (ANC). Sixty adult male rats were randomly distributed into six experimental groups as follows: control, LYC (5 mg/kg), ANC (200 mg/kg), ERY (20 mg/kg), ERY + LYC, and ERY + ANC. After 3 and 6 weeks of treatment, ERY (20 mg/kg) produced marked biochemical and hepatic injuries. ERY significantly reduced the total protein (from 6.93 g/dL in control to 5.33 g/dL) and albumin (from 2.65 to 1.77 g/dL,

Indexed as

anthocyaninerythrosinehepatic functionlycopeneprotective effectsratssynthetic dyes

Identifiers

PMID41585869
PMCPMC12823937

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.