ArticleFrontiers in endocrinology2025
Amelioration of polycystic ovarian morphology by Tokishakuyakusan in a PCOS rat model: association with bone morphogenetic protein 4.
Article in Frontiers in endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed.
- Periestropause enhances hypoxia-induced panic and microglial remodelling without altering respiratory control.Journal of neuroendocrinology · 2026Article
- Synergistic modulation of insulin resistance and ovarian oxidative stress by alpha-lipoic acid and vitamin D in an experimental rat model of polycystic ovary syndrome.Scientific reports · 2026Article
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15 authors.
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Abstract
Background: Polycystic ovary syndrome (PCOS) is a common cause of irregular menstrual cycles and infertility. Current treatments primarily involve ovulation induction and sex steroid hormone therapy. Tokishakuyakusan (TSS) is a traditional Japanese medicine used for reproductive disorders. Bone morphogenetic protein 4 (BMP4), a regulator of follicular growth and steroidogenesis, may contribute to PCOS pathophysiology. This study aimed to investigate the effects of TSS on ovarian morphology, gene expression profiles, and steroidogenesis in a PCOS rat model. Methods: A Wistar rat model of PCOS was generated through prenatal dihydrotestosterone (DHT) exposure. Model rats were fed either a normal diet (DHT group) or a 3% TSS-supplemented diet (DHT+TSS group). Vehicle-treated control rats received a normal diet (vehicle group). Estrous cyclicity and ovarian histology were evaluated. Ovarian gene expression profiling and Western blot analyses were performed. Primary granulosa cells (GCs) isolated from healthy and model rats were treated with human follicle-stimulating hormone (FSH) and TSS to assess underlying mechanisms. Results: PCOS-like phenotypes, including irregular estrous cycles and polycystic ovaries with atretic cyst-like follicles, were observed in the DHT group. Compared with the DHT group, the DHT+TSS group showed a reduced number of atretic cyst-like follicles and improved estrous cyclicity. Ovarian gene expression profiling revealed lower Conclusion: TSS ameliorated PCOS-like ovarian histopathology in prenatally DHT-treated rats and enhanced progesterone production by upregulating
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