SynthesisFrontiers in endocrinology2025
Association between thyroid dysfunction and prognosis in patients with liver failure: a systematic review and meta-analysis.
Synthesis in Frontiers in endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: To systematically evaluate the association between thyroid dysfunction and prognosis in patients with liver failure. Methods: We systematically searched PubMed, Embase, Web of Science (WOS), and China National Knowledge Infrastructure (CNKI) till August 2025 to identify prospective or retrospective studies assessing the relationship between thyroid function-specifically, thyroid-stimulating hormone (TSH), free triiodothyronine (FT3), and free thyroxine (FT4)-and outcomes in adult patients with liver failure, including mortality, intensive care unit (ICU) admission, and organ failure. Study quality was evaluated using the Newcastle-Ottawa Scale (NOS). Pooled relative risks (RRs) with 95% confidence intervals (CIs) were calculated, and heterogeneity, subgroup, and sensitivity analyses were conducted. Results: Eleven studies, including 3,595 patients from four countries, were included. Thyroid dysfunction was significantly associated with increased mortality in patients with liver failure (RR = 3.56, 95% CI: 2.77-4.57; Conclusions: Thyroid dysfunction, particularly low FT3 levels, is associated with higher mortality rates in patients with liver failure. These findings suggest that routine thyroid function assessment may help identify high-risk patients. Further well-designed prospective studies are needed to clarify the underlying mechanisms and evaluate the potential therapeutic implications.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.