Evidence map›Paper›PMID 41585755›Full record

ArticleStroke (Hoboken, N.J.)2023

Rescue Endovascular Treatment of Patients With Emergent Large Vessel Occlusion Attributed to Intracranial Atherosclerosis: A Systematic Review and Meta-Analysis.

Eyad Almallouhi, Mohammad Hassan Murad, Reda Chalhoub, Kimberly P Kicielinski, Jonathan Lena, Emily A Brennan, Osama Zaidat, Adam de Havenon, Alejandro M Spiotta, Sami Al Kasab

Abstract read
In one paragraph

Article in Stroke (Hoboken, N.J.), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Management of intracranial arterial stenosis during mechanical thrombectomy: Survey of neuro-interventionalists.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2026
    Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Review
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Eyad AlmallouhiDepartment of Neurosurgery Medical University of South Carolina Charleston SC.ORCID https://orcid.org/0000-0002-6873-7901
Mohammad Hassan MuradKern Center for the Science of Healthcare Delivery Mayo Clinic Hospital Rochester MN.
Reda ChalhoubDepartment of Neurosurgery Medical University of South Carolina Charleston SC.
Kimberly P KicielinskiDepartment of Neurosurgery Medical University of South Carolina Charleston SC.
Jonathan LenaDepartment of Neurosurgery Medical University of South Carolina Charleston SC.
Emily A BrennanDepartment of Research and Education Services (Libraries) Medical University of South Carolina Charleston SC.
Osama ZaidatDepartment of Endovascular Neurology and Neuroscience Mercy Health St. Vincent Medical Center Toledo OH.
Adam de HavenonDepartment of Neurology Yale University New Haven CT.
Alejandro M SpiottaDepartment of Neurosurgery Medical University of South Carolina Charleston SC.
Sami Al KasabDepartment of Neurosurgery Medical University of South Carolina Charleston SC.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Patients with acute stroke presenting with large vessel occlusion secondary to intracranial atherosclerosis (ICAS-LVO) may require rescue therapy (RT) in addition to mechanical thrombectomy to achieve and maintain successful recanalization. We performed a systematic review and meta-analysis of comparative studies that reported outcomes of RT in patients with ICAS-LVO to evaluate its safety and efficacy. Methods: Databases searched include PubMed, CINAHL Complete, and Scopus from database date of inception through August 17, 2021. We included comparative studies that reported the outcomes of ICAS-LVO RT compared with outcomes of patients with ICAS-LVO who did not undergo RT or to those patients presenting with embolic large vessel occlusion (non-ICAS-LVO). Meta-analysis using the random-effects model was used to combine estimates reporting odds ratios (ORs) and 95% CIs. Results: A total of 9 nonrandomized studies were included: 5 studies in ICAS-LVO RT versus ICAS-LVO non-RT analysis and 5 in ICAS-LVO RT versus non-ICAS LVO analysis. Rescue treatments included intra-arterial antiplatelets, angioplasty, stenting, or a combination of treatments. Compared with non-RT ICAS-LVO, RT was associated with an increased favorable 90-day outcome (OR, 3.19 [95% CI, 1.91-5.32]; Conclusions: Rescue treatment is likely associated with better outcomes in patients with ICAS-LVO. The outcomes of patients with ICAS-LVO who receive RT may be comparable with patients with embolic large vessel occlusion (non-ICAS-LVO).

Indexed as

angioplastyICADintracranial atheroscelrosismechanical thrombectomyrescue therapystentingstroke

Identifiers

PMID41585755
PMCPMC12778592

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.