ArticleACS omega2026
A Comparative Study on the Iron and Copper Binding Properties of 8‑Hydroxyquinoline-Derived Mannich Bases Targeting Multidrug-Resistance Cancer Cells.
Article in ACS omega, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
1 citing paper in PubMed.
- Design and Biological Evaluation of Mannich-Modified 8-Hydroxyquinoline-Phthalimide Hybrids Against Drug-Resistant Cancer Cells.Pharmaceuticals (Basel, Switzerland) · 2026Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The efficacy of 8-hydroxyquinoline (HQ) Mannich bases against multidrug-resistant (MDR) cancer cells is thought to be linked to the complexation with essential metal ions such as iron and copper. Here, the complex formation equilibria of five MDR-selective HQs with Fe-(II), Fe-(III), and Cu-(II) were studied by UV-visible spectrophotometry, complemented by electron paramagnetic resonance, circular dichroism, and electrospray ionization mass spectrometry techniques. Cyclic voltammetry and spectroelectrochemistry were used to map the redox characteristics of the complexes, and their direct reactivity with glutathione was also monitored. Single-crystal X-ray diffraction was applied to determine the structures of one of the selected ligands (HQCl-l-Pro) and its bis-ligand Cu-(II) complex. The ligands are coordinated to Fe-(II) and Fe-(III) via the (N,O
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