Evidence map›Paper›PMID 41585727›Full record

ArticleACS omega2026

Study on the Binding of Five Plant-Derived Secondary Metabolites to G‑Quadruplexes.

Lucie Vrtalová, Michaela Dobrovolná, Daniel Platero-Rochart, Aleksandra L Ptaszek, Václav Brázda, Pedro A Sánchez-Murcia

Abstract read
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In one paragraph

Article in ACS omega, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Lucie VrtalováInstitute of Biophysics of the Czech Academy of Sciences, Královopolská 135, Brno 612 00, Czech Republic.
Michaela DobrovolnáInstitute of Biophysics of the Czech Academy of Sciences, Královopolská 135, Brno 612 00, Czech Republic.
Daniel Platero-RochartLaboratory of Computer-Aided Molecular Design, Division of Medicinal Chemistry, Otto-Loewi Research Center, Medical University of Graz, Neue Stiftingtalstrasse 6/III, Graz 8010, Austria.ORCID https://orcid.org/0000-0001-6454-4320
Aleksandra L PtaszekLaboratory of Computer-Aided Molecular Design, Division of Medicinal Chemistry, Otto-Loewi Research Center, Medical University of Graz, Neue Stiftingtalstrasse 6/III, Graz 8010, Austria.
Václav BrázdaInstitute of Biophysics of the Czech Academy of Sciences, Královopolská 135, Brno 612 00, Czech Republic.ORCID https://orcid.org/0000-0003-2837-4226
Pedro A Sánchez-MurciaLaboratory of Computer-Aided Molecular Design, Division of Medicinal Chemistry, Otto-Loewi Research Center, Medical University of Graz, Neue Stiftingtalstrasse 6/III, Graz 8010, Austria.ORCID https://orcid.org/0000-0001-8415-870X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chemical targeting of noncanonical secondary structures of DNA and RNA has emerged as a promising approach for therapeutic development. The most promising targets seem to be four-stranded structures in the G-rich regions of the genome, known as G-quadruplexes (G4s), which are associated with important regulatory regions including promoters. In this study, we tested and modeled the binding of five plant-derived secondary metabolites, known for their antiproliferative activity in vitro, to two G4s found in the human genome: the first at the

Identifiers

PMID41585727
PMCPMC12824740

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.