Evidence map›Paper›PMID 41585662›Full record

ArticleACS omega2026

Cold Atmospheric Plasma Promotes Anti-Inflammatory and Regenerative Responses in Oral Soft Tissue through Redox-Driven Mitochondrial Regulation.

Tien Ngoc Thuy Nguyen, Byung-Hoon Kim

Abstract read
In one paragraph

Article in ACS omega, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Tien Ngoc Thuy NguyenConvergence research center for treatment of oral soft tissue disease (MRC), Chosun University, Gwangju 61452, Republic of Korea.ORCID https://orcid.org/0009-0008-9310-8139
Byung-Hoon KimConvergence research center for treatment of oral soft tissue disease (MRC), Chosun University, Gwangju 61452, Republic of Korea.ORCID https://orcid.org/0000-0002-5008-1465

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cold atmospheric plasma (CAP) offers a promising therapeutic approach for controlling inflammation and stimulating soft-tissue regeneration within the oral cavity. In this study, human gingival fibroblasts (HGF-1) challenged with lipopolysaccharide (LPS) were treated with helium-based CAP to elucidate how redox-driven mitochondrial regulation mediates its biological effects. Optical emission spectroscopy and infrared thermography verified that the helium dielectric barrier discharge system generated a nonthermal, chemically reactive plasma plume rich in reactive oxygen and nitrogen species (RONS). Controlled CAP exposure transiently elevated intracellular hydrogen peroxide (H

Identifiers

PMID41585662
PMCPMC12824819

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.