ArticleFrontiers in veterinary science2025
Molecular profiling of signaling pathways involved in chicken ovarian follicle development by transcriptome sequencing.
Article in Frontiers in veterinary science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Differences in Reproductive Performance Between Shiqi and Dabao Pigeons: Insights from Multi-Omics Analysis.Genes · 2026Article
- Effects of replacing extruded soybean meal with Periplaneta americana residue on laying performance, egg quality, and ovarian transcriptomic profiles in Guangxi Yao chickens.Poultry science · 2026Article
- FOXO3 regulated granulosa cells apoptosis and AKT1 phosphorylation in Muscovy duck follicles (Cairina moschata).Poultry science · 2026Article
- Osteoarthritis and dementia: contrasting disorders driven by mutual pathways of autophagy, mTOR, GLP-1, AMPK, Wnt, and WISP1.Expert review of clinical pharmacology · 2026Review
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4 authors.
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Abstract
Ovarian follicle development in chickens is a dynamic and closely controlled biological process crucial to avian reproduction. Each stage of folliculogenesis is characterized by distinct morphological and molecular alterations, regulated by complex signaling pathways. This study employed transcriptome sequencing to investigate the molecular landscape that governs the transition from primordial (PR) to primary (PM), small white (SW), and small yellow (SY) follicles. We found stage-specific activation of critical signaling pathways involved in follicle growth and development using thorough differential gene expression and pathway enrichment analyses. Our findings showed that the PI3K/AKT/mTOR signaling pathway was highly elevated throughout the shift from PR to PM follicles, highlighting its importance in beginning cellular proliferation and protein synthesis. During development, the Wnt signaling system was regulated from the PM to the SW follicles. This included
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