Evidence map›Paper›PMID 41585490›Full record

ArticleiScience2026

Synthetic zipper mediated pre-targeting system for near-infrared photoimmunotherapy.

T M Mohiuddin, Chaoyu Zhang, Wenjie Sheng, Marwah Al-Rawe, Natalia El-Merhie, Felix Zeppernick, Ivo Meinhold-Heerlein, Ahmad Fawzi Hussain

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

T M MohiuddinDepartment of Gynecology and Obstetrics, Medical Faculty, Justus-Liebig-University Giessen, Klinikstr. 33, 35392 Giessen, Germany.
Chaoyu ZhangDepartment of Gynecology and Obstetrics, Medical Faculty, Justus-Liebig-University Giessen, Klinikstr. 33, 35392 Giessen, Germany.
Wenjie ShengDepartment of Gynecology and Obstetrics, Medical Faculty, Justus-Liebig-University Giessen, Klinikstr. 33, 35392 Giessen, Germany.
Marwah Al-RaweDepartment of Gynecology and Obstetrics, Medical Faculty, Justus-Liebig-University Giessen, Klinikstr. 33, 35392 Giessen, Germany.
Natalia El-MerhieInstitute for Lung Health (ILH), Cardiopulmonary Institute (CPI), Member of the German Center for Lung Research (DZL), Justus Liebig University Giessen, Aulweg 128, 35392 Giessen, Germany.
Felix ZeppernickDepartment of Gynecology and Obstetrics, Medical Faculty, Justus-Liebig-University Giessen, Klinikstr. 33, 35392 Giessen, Germany.
Ivo Meinhold-HeerleinDepartment of Gynecology and Obstetrics, Medical Faculty, Justus-Liebig-University Giessen, Klinikstr. 33, 35392 Giessen, Germany.
Ahmad Fawzi HussainDepartment of Gynecology and Obstetrics, Medical Faculty, Justus-Liebig-University Giessen, Klinikstr. 33, 35392 Giessen, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Several strategies have gained attraction in cancer diagnosis and therapy, particularly to overcome the limitations associated with direct targeting approaches in radioimmunotherapy and photoimmunotherapy. Here, we have introduced a synthetic zipper-mediated pre-targeting system for near-infrared photoimmunotherapy (NIR-PIT) utilizing the IR700-conjugated Zip1-SNAP protein in combination with three scFv-ZIP2 fusion proteins targeting FOLR1, TROP2, and TF. In this two-step targeting approach, scFv-Zip2 proteins first bind to cancer-specific antigens, followed by hybridization with Zip1-SNAP-IR700 at cell surface via high-affinity zipper interaction. Upon NIR light irradiation, targeted cancer cells underwent selective phototoxicity in a concentration-dependent manner with IC

Indexed as

biological sciencescancercell biologyconjugatedrug delivery system

Identifiers

PMID41585490
PMCPMC12830222

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.