ArticleiScience2026
Advanced human organoid-on-chip with physiological cellular complexity reveals bidirectional secretion patterns.
Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Progress and challenges in the development of advanced pancreatic cancer organoids.Journal of experimental & clinical cancer research : CR · 2026Review
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Intestinal epithelial cells are essential for maintaining gut homeostasis, serving as a physical barrier separating luminal content from the immune compartment. They are crucial for balancing tolerance to commensal and protection from pathogenic bacteria and dietary antigens by the asymmetric secretion of immune regulators. To understand how different epithelial cell types and external stimuli shape this secretion pattern, we established and characterized a human intestinal organoid-on-chip (OoC) model. OoCs were used to evaluate barrier integrity and cell type-dependent expression profiles by RNA-sequencing and microscopy. Secretome analysis revealed asymmetric bidirectional secretion and a cell type-dependent response to LPS, flagellin, gliadin, and cytokines. In summary, we have developed an OoC model using human intestinal cells, offering a cutting-edge platform to study barrier function under physiological and pathophysiological conditions. This versatile tool holds significant promise for advancing our understanding of epithelial cells in innate immunity and driving the development of personalized therapeutic strategies.
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