Evidence map›Paper›PMID 41585468›Full record

ArticleImaging neuroscience (Cambridge, Mass.)

Monitoring morphometric drift in lifelong learning segmentation of the spinal cord.

Enamundram Naga Karthik, Sandrine Bédard, Jan Valošek, Christoph S Aigner, Elise Bannier, Josef Bednařík, Virginie Callot, Anna Combes, Armin Curt, Gergely David and 45 more

Abstract read
In one paragraph

Article in Imaging neuroscience (Cambridge, Mass.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Spinal cord imaging in multiple sclerosis: A vital component we can no longer overlook.Multiple sclerosis (Houndmills, Basingstoke, England) · 2026
    Pooled it
  2. Article
  3. Charting Cervical Spinal Cord Morphometry Across the Lifespan.bioRxiv : the preprint server for biology · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Rootlets-based registration to the PAM50 spinal cord template.Imaging neuroscience (Cambridge, Mass.) · 2025
    Article
  9. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

55 authors.

Enamundram Naga KarthikNeuroPoly Lab, Institute of Biomedical Engineering, Polytechnique Montreal, Montreal, QC, Canada.ORCID https://orcid.org/0000-0003-2940-5514
Sandrine BédardNeuroPoly Lab, Institute of Biomedical Engineering, Polytechnique Montreal, Montreal, QC, Canada.
Jan ValošekNeuroPoly Lab, Institute of Biomedical Engineering, Polytechnique Montreal, Montreal, QC, Canada.
Christoph S AignerPhysikalisch-Technische Bundesanstalt (PTB), Braunschweig and Berlin, Germany.
Elise BannierDepartment of Neuroradiology, Rennes University Hospital, Rennes, France.
Josef BednaříkDepartment of Neurology, University Hospital Brno, Brno, Czechia.
Virginie CallotAix-Marseille Univ, CNRS, CRMBM, Marseille, France.
Anna CombesNMR Research Unit, Queen Square Multiple Sclerosis Centre, UCL Queen Square Institute of Neurology, University College London, London, United Kingdom.
Armin CurtSpinal Cord Injury Center, Balgrist University Hospital, University of Zurich, Zurich, Switzerland.
Gergely DavidSpinal Cord Injury Center, Balgrist University Hospital, University of Zurich, Zurich, Switzerland.
Falk EippertMax Planck Research Group Pain Perception, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany.
Lynn FarnerSpinal Cord Injury Center, Balgrist University Hospital, University of Zurich, Zurich, Switzerland.
Michael G FehlingsDivision of Neurosurgery and Spine Program, Department of Surgery, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.
Patrick FreundSpinal Cord Injury Center, Balgrist University Hospital, University of Zurich, Zurich, Switzerland.
Tobias GranbergDepartment of Neuroradiology, Karolinska University Hospital, Stockholm, Sweden.
Cristina GranzieraTranslational Imaging in Neurology (ThINk), Department of Biomedical Engineering, Faculty of Medicine, Basel, Switzerland.
Ulrike HornMax Planck Research Group Pain Perception, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany.
Tomáš HorákDepartment of Neurology, University Hospital Brno, Brno, Czechia.
Suzanne HumphreysPraxis Spinal Cord Institute, Vancouver, BC, Canada.
Markus HuppSpinal Cord Injury Center, Balgrist University Hospital, University of Zurich, Zurich, Switzerland.
Anne KerbratEMPENN Research Team, IRISA, CNRS‑INSERM‑INRIA, Rennes Université, Rennes, France.
Nawal KinanyNeuro-X Institute, Ecole Polytechnique Fédérale de Lausanne (EPFL), Geneva, Switzerland.
Shannon KolindDivision of Neurology, Department of Medicine and the Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC, Canada.
Petr KudličkaFaculty of Medicine, Masaryk University, Brno, Czechia.
Anna LebretSpinal Cord Injury Center, Balgrist University Hospital, University of Zurich, Zurich, Switzerland.
Lisa Eunyoung LeeInstitute of Medical Science, University of Toronto, Toronto, ON, Canada.
Caterina MaineroAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, USA; Harvard Medical School, Boston, MA, United States.
Allan R MartinDepartment of Neurosurgery, University of California Davis, Davis, CA, United States.
Megan McGrathVanderbilt University Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, TN, United States.
Govind NairqMRI Core Facility, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, United States.
Kristin P O'GradyVanderbilt University Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, TN, United States.
Jiwon OhBarlo MS Centre, Division of Neurology, Department of Medicine, St. Michael's Hospital, Toronto, Canada.
Russell OuelletteDepartment of Neuroradiology, Karolinska University Hospital, Stockholm, Sweden.
Nikolai PfenderSpinal Cord Injury Center, Balgrist University Hospital, University of Zurich, Zurich, Switzerland.
Dario PfyfferSpinal Cord Injury Center, Balgrist University Hospital, University of Zurich, Zurich, Switzerland.
Pierre-François PradatDepartment of Neurology, Pitie-Salpetriere Hospital, Paris, France.
Alexandre PratDepartment of Neuroscience, Université de Montréal, Montréal, QC, Canada.
Emanuele PravatàDepartment of Neuroradiology, Neurocenter of Southern Switzerland, Lugano, Switzerland.
Daniel S ReichTranslational Neuroradiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, United States.
Ilaria RicchiNeuro-X Institute, Ecole Polytechnique Fédérale de Lausanne (EPFL), Geneva, Switzerland.
Naama Rotem-KohaviPraxis Spinal Cord Institute, Vancouver, BC, Canada.
Simon Schading-SassenhausenSpinal Cord Injury Center, Balgrist University Hospital, University of Zurich, Zurich, Switzerland.
Maryam SeifSpinal Cord Injury Center, Balgrist University Hospital, University of Zurich, Zurich, Switzerland.
Andrew SmithDepartment of Physical Medicine and Rehabilitation, University of Colorado School of Medicine, Aurora, CO, United States.
Seth A SmithVanderbilt University Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, TN, United States.
Grace SweeneyVanderbilt University Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, TN, United States.
Roger TamSchool of Biomedical Engineering, Department of Radiology, The University of British Columbia, Vancouver, BC, Canada.
Anthony TraboulseeDepartment of Medicine, Division of Neurology, University of British Columbia, BC, Canada.
Constantina Andrada TreabaAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, USA; Harvard Medical School, Boston, MA, United States.
Charidimos TsagkasTranslational Neuroradiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, United States.
Zachary VavasourSchool of Biomedical Engineering, Department of Radiology, The University of British Columbia, Vancouver, BC, Canada.
Dimitri Van De VilleNeuro-X Institute, Ecole Polytechnique Fédérale de Lausanne (EPFL), Geneva, Switzerland.
Kenneth Arnold Weber IiDivision of Pain Medicine, Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Palo Alto, CA, United States.
Sarath ChandarMila-Quebec AI Institute, Montreal, QC, Canada.
Julien Cohen-AdadNeuroPoly Lab, Institute of Biomedical Engineering, Polytechnique Montreal, Montreal, QC, Canada.

Funding

Cortical mechanisms of disease progression in early multiple sclerosisR01NS078322 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI MAINERO, CATERINA · 2013 to 2017
$1.9M
NINDS NIH HHS R01 NS078322
6 · The paper itself

Abstract

Morphometric measures derived from spinal cord segmentations can serve as diagnostic and prognostic biomarkers in neurological diseases and injuries affecting the spinal cord. For instance, the spinal cord cross-sectional area can be used to monitor cord atrophy in multiple sclerosis and to characterize compression in degenerative cervical myelopathy. While robust, automatic segmentation methods to a wide variety of contrasts and pathologies have been developed over the past few years, whether their predictions are stable as the model is updated using new datasets has not been assessed. This is particularly important for deriving normative values from healthy participants. In this study, we present a spinal cord segmentation model trained on a multisite (

Indexed as

lifelong learningMLOpsmorphometric driftMRIsegmentationspinal cord

Identifiers

PMID41585468
PMCPMC12828353

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.