ArticleNeurophotonics2026
Cross-paradigm fNIRS brain activity in 1-month-old infants across The Gambia and the United Kingdom.
Article in Neurophotonics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Functional specialisation across the first five years of life: A longitudinal characterisation of social perception with fNIRS.Imaging neuroscience (Cambridge, Mass.) · 2026Article
- Effect of sleep stage on patterns of fNIRS hemodynamic response to auditory paradigms in 1-month-old Gambian and UK infants.Neurophotonics · 2026Article
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13 authors.
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Abstract
Significance: Neonates undergo rapid development, yet the examination of emerging brain markers across paradigms, cognitive domains, and diverse global populations remains limited. Aim: We investigated whether brain responses at 1 month of age could be interrogated across paradigms to offer deeper context-specific insights into neurodevelopment. Approach: Functional near-infrared spectroscopy was used to assess frontal and temporal brain responses during natural sleep in 181 infants from a low-income setting (rural Gambia) and 58 infants from a higher-income setting (Cambridge, United Kingdom) during three auditory paradigms: social selectivity, habituation and novelty detection, and functional connectivity. Paradigm-level brain responses were analyzed using threshold-free cluster enhancement and cross-paradigm comparisons of individual responses. Results: Both Gambian and UK infants showed habituation but not novelty responses, higher inter- versus intra-hemispheric connectivity, stronger inter-hemispheric connectivity in temporal relative to frontal regions, stronger inter-regional connectivity between right temporal and left frontal regions, and nonvocal > vocal selectivity (UK infants only). Conclusions: Cross-cohort differences in the cross-paradigm analyses suggest that context-specific developmental markers are evident within the first month of life and show high individual variability. Cross-paradigm analyses revealed that greater vocal selectivity (UK) is associated with higher inter-hemispheric connectivity, potentially allowing us to identify biomarkers of more mature neurodevelopment within the first weeks of postnatal life.
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