Exosomal miRNA-218-5p derived from low-passage dermal papilla cells modulates hair follicle growth and development.

Bohao Zhao, Jiawei Cai, Miaocheng Wang, Jiali Li, Shuyu Yao, Zhiyuan Bao, Yang Chen, Xinsheng Wu

Abstract read

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Article in Non-coding RNA research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

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3 · Its place in the literature

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1 citing paper in PubMed.

MiR-376c-3p Targets STRBP mRNA to Regulate Cashmere Goat Hair Follicle Stem Cell Proliferation and Multipotency by Inhibiting the Wnt/β-Catenin and BMP Signaling Pathways.Animal genetics · 2026
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8 authors.

Bohao ZhaoCollege of Animal Science and Technology, Yangzhou University, 225009, Yangzhou, Jiangsu, China.

Jiawei CaiCollege of Animal Science and Technology, Yangzhou University, 225009, Yangzhou, Jiangsu, China.

Miaocheng WangCollege of Animal Science and Technology, Yangzhou University, 225009, Yangzhou, Jiangsu, China.

Jiali LiCollege of Animal Science and Technology, Yangzhou University, 225009, Yangzhou, Jiangsu, China.

Shuyu YaoCollege of Animal Science and Technology, Yangzhou University, 225009, Yangzhou, Jiangsu, China.

Zhiyuan BaoCollege of Animal Science and Technology, Yangzhou University, 225009, Yangzhou, Jiangsu, China.

Yang ChenCollege of Animal Science and Technology, Yangzhou University, 225009, Yangzhou, Jiangsu, China.

Xinsheng WuCollege of Animal Science and Technology, Yangzhou University, 225009, Yangzhou, Jiangsu, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Exosomes are nanoscale particles that participate in multiple biological processes and are secreted by various cell types. Exosomes derived from dermal papilla cells (DPC-Exos) regulate hair follicle (HF) growth and development. In this study, HF development-related genes were significantly expressed in low-passage dermal papilla cells (DPCs). Low-passage DPC-Exos promoted hair follicle stem cell (HFSC) proliferation. After the collection of DPC-Exos, miRNA sequencing identified 36 differentially expressed (DE) miRNAs between low-passage and high-passage DPC-Exos. Among these, miR-218-5p was significantly upregulated in low-passage DPC-Exos and dysregulated HF growth and development-related gene expression in HFSCs. Furthermore, the transport mechanism of exosomal miR-218-5p from DPCs is into HFSCs was verified. RNA sequencing of HFSCs treated with exosomal miR-218-5p identified differentially expressed genes (DEGs). The results indicated involvement of miR-218-5p in signaling pathways related to HF growth and development. Additionally,

Indexed as

ExosomeHair follicle growthmiR-218–5p

Identifiers

PMID41585345

DOI10.1016/j.ncrna.2026.01.004

PMCPMC12830253

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