ArticleFrontiers in medicine2025
Maternal inflammatory biomarkers and neonatal characteristics as predictors of bronchopulmonary dysplasia in preterm infants: a retrospective cohort study.
Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Maternal peripartum inflammation may contribute to bronchopulmonary dysplasia (BPD) in preterm infants, yet readily available hematologic predictors are underexplored. We evaluated whether the maternal platelet-to-white blood cell ratio (PWR) within 24 h before delivery, together with neonatal clinical variables, predicts BPD. Methods: We conducted a retrospective cohort study at a tertiary NICU in Southwest China, including all eligible mother-infant pairs with preterm birth (<37 weeks) between June 2020 and June 2024. BPD was defined per the 2018 NICHD criteria. Maternal demographics, obstetric complications, hematology (WBC, PLT, PWR, NLR, and PLR), and neonatal characteristics (gestational age, birth weight, sex, Apgar score, SGA, sepsis, and respiratory support) were abstracted from electronic records. Variables with Results: Among 345 pairs, 117 infants (33.9%) developed BPD. Mothers of BPD infants had higher WBC and lower PLT, yielding a lower PWR (median 18.9 vs. 23.1, Conclusion: A lower maternal PWR measured immediately before delivery, alongside established neonatal risk factors, independently predicts BPD in preterm infants. This simple hematologic marker, integrated into a nomogram, may facilitate early identification and targeted prevention strategies in high-risk dyads.
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