SynthesisFrontiers in medicine2025
Association between stress hyperglycemia ratio and all-cause mortality among ICU patients with sepsis: a systematic review and meta-analysis.
Synthesis in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Longitudinal Stress Hyperglycemia Trajectories and Severe Outcome in Patients Hospitalized for Viral Respiratory Infections: A 72-Hour Phenotyping Study.Diagnostics (Basel, Switzerland) · 2026Article
- The Diabetes-Viral Respiratory Syndemic: Pathophysiological Insights and Precision Management: A Scoping Review.Medicina (Kaunas, Lithuania) · 2026Article
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: The stress hyperglycemia ratio (SHR) is defined as the admission blood glucose level divided by the estimated average glucose derived from glycated hemoglobin (HbA1c). Previous studies have demonstrated that higher SHR levels are associated with increased all-cause mortality among intensive care unit (ICU) patients. However, the relationship between SHR and mortality risk specifically in patients with sepsis remains controversial. Objectives: This study aimed to systematically evaluate, through a systematic review and meta-analysis, the association between SHR and all-cause mortality among adult ICU patients with sepsis. Methods: A comprehensive search was performed in PubMed, Web of Science, Embase, and the Cochrane Library databases. The methodological quality of included studies was assessed using the Newcastle-Ottawa Scale (NOS). A random-effects model was employed to pool relative risks (RR) with corresponding 95% confidence intervals (CIs). All statistical analyses were conducted using Stata version 18.0. Results: A total of 11 retrospective cohort studies comprising 37,790 participants were included. Pooled analyses showed that higher SHR levels were significantly associated with increased risks of in-hospital mortality (RR = 2.11, 95% CI: 1.79-2.50; Conclusion: This systematic review and meta-analysis demonstrated that elevated SHR is an independent predictor of in-hospital, short-term, and long-term all-cause mortality among ICU patients with sepsis. SHR, as a simple and valuable prognostic biomarker, may aid in early risk stratification of patients with sepsis. Systematic review registration: https://www.crd.york.ac.uk/PROSPERO/view/CRD420251139874, Identifier CRD420251139874.
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