ArticleJournal of dental sciences2026
Development of bio-compatible isosorbide-based polyurethanes exhibiting eucalyptol solubility for advanced root canal filling applications.
Article in Journal of dental sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
5 authors.
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Abstract
Background/purpose: Gutta-percha (GP) has long been the standard root canal filling material, but its poor removability, limited mechanical properties, and potential cytotoxicity restrict clinical performance. To address these shortcomings, this study aimed to develop bio-based D-isosorbide thermoplastic polyurethanes (IPUs) with improved removability in eucalyptol oil, superior mechanical performance, and enhanced cytocompatibility, providing a potential alternative to GP. Materials and methods: D-isosorbide-based IPUs were synthesized from polycarbonate polyol and D-isosorbide via catalyst-free, two-step polymerization. Four formulations with different hard segment contents (HS10-HS40) were prepared and evaluated for thermal stability (thermogravimetric analysis and differential scanning calorimetry), mechanical properties (tensile testing), solubility in eucalyptol oil, and cytocompatibility (CCK-8 and LDH assays), compared with GP. Results: All IPUs showed high thermal stability (T Conclusion: D-isosorbide-based IPUs combine favorable thermal and mechanical properties with partial solubility in eucalyptol, enabling easier and safer retreatment. Their excellent cytocompatibility further supports their potential as sustainable and clinically viable alternatives to GP in root canal obturation.
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