Evidence map›Paper›PMID 41585151›Full record

ArticleJournal of dental sciences2026

Novel

Shih-Kai Wang, Hong Zhang, Hua-Chieh Lin, Yin-Lin Wang, J Timothy Wright, John D Bartlett, James P Simmer, Jan C-C Hu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of dental sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Integrative multi-omics and bioinformatic analysis ofThe Japanese dental science review · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Shih-Kai WangDepartment of Dentistry, National Taiwan University School of Dentistry, Taipei City, Taiwan.
Hong ZhangDepartment of Biologic and Materials Sciences, University of Michigan School of Dentistry, Ann Arbor, MI, USA.
Hua-Chieh LinDepartment of Dentistry, National Taiwan University School of Dentistry, Taipei City, Taiwan.
Yin-Lin WangDepartment of Dentistry, National Taiwan University School of Dentistry, Taipei City, Taiwan.
J Timothy WrightDepartment of Pediatric Dentistry, University of North Carolina School of Dentistry, Chapel Hill, NC, USA.
John D BartlettDivision of Biosciences, The Ohio State University, College of Dentistry, Columbus, OH, USA.
James P SimmerDepartment of Biologic and Materials Sciences, University of Michigan School of Dentistry, Ann Arbor, MI, USA.
Jan C-C HuDepartment of Biologic and Materials Sciences, University of Michigan School of Dentistry, Ann Arbor, MI, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background/purpose: Matrix metalloproteinase 20 (MMP20) is a proteinase essential for dental enamel formation. Mutations in human Materials and methods: Whole-exome analyses and Sanger sequencing were performed to identify and confirm disease-causing mutations. To evaluate the pathogenicity of identified Results: All affected individuals from the five families exhibited similar dental phenotypes, including chalky-white to yellow-brown discolorations and evident dental attrition. The defective enamel was both thin and hypomineralized. Six pathogenic Conclusion: This study expands the genotypic spectrum of

Indexed as

BiomineralizationCatalytic domainEnamel matrix proteinsMetzincinPathogenic variantProteolysis

Identifiers

PMID41585151
PMCPMC12825509

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.