ArticleJournal of dental sciences2026
Long non-coding RNA PP7080 enhances cancer stemness and tumorigenic features in oral cancer.
Article in Journal of dental sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
1 citing paper in PubMed.
- Biomarkers of Treatment Response in Paediatric Medulloblastoma.Diagnostics (Basel, Switzerland) · 2026Review
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background/purpose: Emerging evidence has shown that various failures in cancer therapy, such as drug resistance, metastasis, and cancer relapse are attributed to cancer stem cells (CSCs). Also, growing attention has been paid to the regulation of non-coding RNAs in cancer stemness. Here, we aimed to investigate the impact of lncRNA PP7080 on cancer stemness in oral squamous cell carcinomas. Materials and methods: PP7080 expression was assessed in ALDH1 Results: Our results showed that PP7080 was significantly overexpressed in oral cancer tissues and positively correlated with stemness markers. The phenotypic and flow cytometry assays demonstrated that suppression of PP7080 reduced the migratory and colony-forming aibilities, cancer stemness features, and self-renewal abilities in oral CSCs. Furthermore, we demonstrated that PP7080 may enhance cancer stemness features by counteracting the tumor-suppressive effect of miR-601. Conclusion: Targeting PP7080 may offer a promising therapeutic strategy for oral cancer by reducing cancer stemness.
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