ReviewFrontiers in neuroscience2025
Structure and function of the blood-brain barrier in perioperative neurocognitive disorders.
Review in Frontiers in neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Optimal prophylaxis for perioperative drug-induced delayed neurocognitive recovery: a Bayesian network meta-analysis of 18 interventions with mechanism-based stratification.Frontiers in pharmacology · 2026Pooled it
- Long-Term Cognitive and Functional Outcomes of Anesthesia and Surgery in Patients with Dementia.Healthcare (Basel, Switzerland) · 2026Review
- The NO-cGMP signaling pathway and depression: mechanisms and therapeutic prospects.Molecular biology reports · 2026Review
- Mapping the Neuroprotective Landscape of Perioperative Magnesium Sulphate: A Translational Scoping Review.Journal of clinical medicine · 2026Review
- Extracellular vesicle signalling in perioperative neurocognitive disorders.Frontiers in immunology · 2026Review
- PreoperativeFrontiers in bioinformatics · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Perioperative neurocognitive disorders (PNDs) are the most common neurological complications in elderly patients undergoing surgery. Patients with PNDs have significantly greater incidences of postoperative disability and mortality. Currently, there are no specific treatments for PNDs. Methods: This review integrates the latest evidence examining the role of structural and functional changes in the blood-brain barrier (BBB) in the pathological mechanisms of PNDs, with the aim of identifying innovative preventive strategies and promising therapeutic targets for PNDs. Results: Researchers have proposed various hypotheses to shed light on the pathogenesis of PNDs, including neuroinflammation, neurotransmitter or receptor abnormalities, beta-amyloid (Aβ) deposition and tau protein phosphorylation, oxidative stress, iron homeostasis imbalance, circadian rhythm disruption, and changes in the gut microbiota. Damage to the BBB plays a critical role in the pathogenesis of PNDs. Conclusion: This article summarizes the role of BBB structural and functional changes in the pathogenesis of PNDs reported in recent studies, with the goal of providing new ideas for preventing and treating PNDs.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.