Evidence map›Paper›PMID 41585038›Full record

ArticleBrain communications2026

Alterations in the brain lipidome of Alzheimer's disease donors with rare

Petroula Proitsi, Amera Ebshiana, Asger Wretlind, Jin Xu, Angela K Hodges, Cristina Legido-Quigley

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Petroula ProitsiCentre for Preventive Neurology, Wolfson Institute of Population Health, Queen Mary University of London, London EC1M 6BQ, UK.
Amera EbshianaInstitute of Pharmaceutical Science, King's College London, London SE1 9NH, UK.
Asger WretlindInstitute of Pharmaceutical Science, King's College London, London SE1 9NH, UK.
Jin XuInstitute of Pharmaceutical Science, King's College London, London SE1 9NH, UK.
Angela K HodgesMaurice Wohl Clinical Neuroscience Institute, Institute of Psychiatry, Psychology and Neuroscience (IoPPN), King's College London, London SE5 9RT, UK.
Cristina Legido-QuigleyInstitute of Pharmaceutical Science, King's College London, London SE1 9NH, UK.ORCID https://orcid.org/0000-0002-4018-214X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Triggering Receptor Expressed on Myeloid Cells 2 (TREM2) is a microglial receptor, sensitive to Phospholipids and Sphingomyelins, associated with neurodegeneration. Hypomorphic variants in the

Indexed as

Alzheimer's diseasebrainlipidomicslipidsTREM2

Identifiers

PMID41585038
PMCPMC12823283

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.