ReviewFrontiers in pediatrics2025
AEIOU strategy for continuous renal replacement therapy in infants <10 kg: a practical and educational framework.
Review in Frontiers in pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Continuous renal replacement therapy (CRRT) has become a cornerstone in the management of critically ill children with severe acute kidney injury (AKI) and fluid overload. However, its use in neonates and infants weighing less than 10 kg remains particularly challenging due to limited circulating volumes, higher risks of hemodynamic instability, and the scarcity of devices specifically designed for this population. In recent years, new platforms have been introduced, enabling safer extracorporeal support for the smallest patients. Although early experiences suggest that these technologies are feasible and safe, survival outcomes in this fragile group remain suboptimal, and standardized guidelines are still lacking. To address this gap, we propose the AEIOU strategy, an educational and practical framework aimed at organizing and simplifying the essential components required for safe and effective CRRT in infants under 10 kg.
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