ArticleNature synthesis2025
Nickel-mediated aerobic C(sp2)-nucleophile coupling reactions for late-stage diversification of aryl electrophiles.
Article in Nature synthesis, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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Who cites it
3 citing papers in PubMed.
- Photoelectrochemistry-Promoted Ni-Catalyzed C-O Cross-Couplings.Precision chemistry · 2025Article
- Persistent acyclic Cp*Ir(III) complexes and their reactivities in cross-coupling reactions.Nature communications · 2025Article
- Nickel-Mediated Aerobic CTrends in chemistry · 2025Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
The structural diversification of pharmaceutically relevant compounds presents unique challenges to catalytic methodologies that have been developed and optimized on simpler substrates that lack drug-like complexity. Herein, we report a general strategy for carbon-heteroatom (C-X) bond formation through reactions between a wide range of nucleophiles and Ni-based oxidative addition complexes (OACs) of drug-like aryl and heteroaryl electrophiles. These organonickel complexes are easily synthesized by oxidative addition of the corresponding electrophiles under electroreductive conditions using an inexpensive Ni precursor. Redox-induced oxidative coupling from these persistent complexes proved challenging, but mechanistic studies guided the development of a simple aerobic oxidation procedure to rapidly form C-X coupled products. Exposure of the organonickel complexes to ambient air forms a high-valent (peroxo)Ni
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Registered trials
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