ArticleStem cells international2026
Astaxanthin Reverses Oxidative Stress-Induced Dysfunction in Human Periodontal Ligament Stem Cells by Activating the Nrf2/ARE Pathway.
Article in Stem cells international, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Astaxanthin Reverses Oxidative Stress-Induced Dysfunction in Human Periodontal Ligament Stem Cells by Activating the Nrf2/ARE Pathway.Stem cells international · 2026Article
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Authors and funding
8 authors.
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Abstract
Background: Oxidative stress plays a crucial role in the pathogenesis of periodontitis and compromises the regenerative potential of human periodontal ligament stem cells (hPDLSCs). Astaxanthin (ASX), a potent natural antioxidant with both lipophilic and hydrophilic properties, has been shown to scavenge reactive oxygen species (ROS). However, its protective effects on hPDLSCs under oxidative stress remain largely unexplored. Methods: hPDLSCs were isolated and characterized. An oxidative stress model was established by exposing cells to 300 μM H Results: ASX significantly reduced intracellular and mitochondrial ROS levels, preserved mitochondrial membrane potential, and inhibited H Conclusion: These findings demonstrate that ASX ameliorates oxidative stress-induced injury in hPDLSCs via the Nrf2/ARE signaling pathway, exerting antioxidative, anti-inflammatory, and pro-osteogenic effects. This suggests its therapeutic potential for promoting periodontal regeneration under oxidative microenvironments.
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