Evidence map›Paper›PMID 41584900›Full record

ArticleEJHaem2026

Hemophagocytic Lymphohistiocytosis as First Manifestation of Dual B-Cell Neoplasms: A Case Report of Co-Existing Multiple Myeloma and B-Cell Lymphoma.

Carla Romagnoli, Alexandra Lyubimova, Leily Santos-Carrion, Ferial Alloush, Vathany Sriganeshan, Andrea Noboa, Jacqueline C Barrientos

Abstract read
In one paragraph

Article in EJHaem, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Carla RomagnoliMount Sinai Comprehensive Cancer Center Miami Beach, Florida USA.ORCID https://orcid.org/0009-0005-8176-2342
Alexandra LyubimovaMount Sinai Comprehensive Cancer Center Miami Beach, Florida USA.
Leily Santos-CarrionMount Sinai Comprehensive Cancer Center Miami Beach, Florida USA.
Ferial AlloushMount Sinai Comprehensive Cancer Center Miami Beach, Florida USA.
Vathany SriganeshanMount Sinai Comprehensive Cancer Center Miami Beach, Florida USA.
Andrea NoboaSociedad de Lucha contra el Cáncer Guayaquil Ecuador.
Jacqueline C BarrientosMount Sinai Comprehensive Cancer Center Miami Beach, Florida USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hemophagocytic lymphohistiocytosis (HLH) is an immune disorder causing excessive inflammation and tissue damage. Lymphoma, especially T-cell lymphoma, is the most common cause of HLH, while Multiple Myeloma (MM) is rarely associated. We present a 61-year-old man with spiking fevers, fatigue, and unintentional weight loss. The HLH was driven by two distinct malignant clones in his bone marrow: plasma cell neoplasm and B-cell lymphoma. Patient failed initial therapy with steroids, anakinra, and chemotherapy. Tocilizumab use, on the other hand, led to an excellent clinical and laboratory response immediately. This is the first reported case of HLH associated with two hematological malignancies.

Indexed as

hemophagocytic lymphohistiocytosishyperinflammationlymphomaplasma cell neoplasmtocilizumab

Identifiers

PMID41584900
PMCPMC12826990

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.