ArticleFrontiers in physiology2025
High-altitude hypoxia exacerbates gastric mucosal damage and regulates the Nrf2 signaling pathway in
Article in Frontiers in physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Methods: Male C57BL/6 mice were randomly divided into four groups: the control group (Con), the hypoxia group (H), the Results: Compared to the H and Hp groups, mice in the HpH group exhibited significantly higher gastric mucosal epithelial damage scores. This group also showed decreased expression of ZO-1, Occludin, and Bcl-2 in gastric tissues, along with increased expression of Bax and Caspase-3. Furthermore, in the HpH group, the gastric levels of MDA, TNF-α, IL-1β, and IL-6 were elevated, while the activities of SOD and GSH-Px were reduced. Additionally, the HpH group displayed increased expression levels of Keap1 in gastric tissues, along with decreased levels of Nrf2 and its downstream target genes HO-1 and NQO1. Discussion: High-altitude hypoxia exacerbates oxidative stress and inflammatory responses induced by
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