ArticleFrontiers in psychiatry2025
Commonalities and differences in trait-like, risky, and utilitarian decision-making styles between abstinent heroin-dependent individuals and their siblings.
Article in Frontiers in psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Heroin dependence is associated with poor performance on laboratory-based decision-making paradigms. However, it remains unclear whether these deficits may have predated drug abuse due to potential familial susceptibilities or emerged as a consequence of chronic drug use. A family study may help clarify this important issue, so this study was to compare various decision-making aspects between heroin-dependent individuals and their siblings. Methods: A total of 70 abstinent heroin-dependent individuals (HAs), 69 unaffected biological siblings of the HAs (Siblings), and 74 unrelated healthy subjects (HCs) were included and tested on trait-like, risky, and utilitarian decision-making domains, using the Melbourne Decision-Making Questionnaire (MDMQ), the Balloon Analogue Risk Task (BART), and the Moral Decision-Making Task (MDMT). Results: Data indicated that both HAs and Siblings scored higher on MDMQ Procrastination (Cohen's Conclusions: These findings suggest that deficits in trait-like and risk-taking-related decision-making styles are shared by abstinent heroin-dependent individuals and their unaffected siblings, which might represent the conceivable markers for potential familial vulnerabilities implicated in the development of heroin dependence.
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