ArticleFrontiers in plant science2025
Integrated metabolomic and transcriptomic profiling elucidates the tissue-specific biosynthesis and regulation of flavonoids in
Article in Frontiers in plant science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Methods: This multi-omics study revealed the specific accumulation pattern of flavonoids in the tissues of Results: A total of 425 flavonoid compounds and 35,671 differentially expressed genes were detected. Further screening revealed 41 structural genes encoding 19 key enzymes (including PAL, CHS, FLS, UGTs, etc.), among which two UGTs (Cluster-69292 and Cluster-71935) were subcellularly localized to the cytoplasm. Furthermore, the weighted gene co-expression network analysis (WGCNA) revealed four key modules exhibiting strong correlations with flavonoid content. From these modules, four core transcription factors (TFs) from the MYB and bHLH families were identified as putative regulators of flavonoid biosynthesis. Discussion: Our findings offer the first comprehensive model of tissue-specific flavonoid accumulation in
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