ArticleJournal of oral and maxillofacial pathology : JOMFP
Comparative evaluation of Plasma and Salivary 8-isoprostane expression in Oral Leukoplakia and Oral Submucous Fibrosis patients.
Article in Journal of oral and maxillofacial pathology : JOMFP. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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3 authors.
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Abstract
Background and Objectives: Among the various biofluids, 8-isoprostane is a relatively underexplored yet stable oxidative stress biomarker that can be detected in measurable quantities. It is a unique by-product of arachidonic acid lipid peroxidation, and in recent years, its expression has been investigated in various diseases, particularly in malignancies. Our study was performed to evaluate the level of 8-isoprostane and compare its expression in plasma and saliva samples of oral leukoplakia (OL), oral submucous fibrosis (OSMF) patients and healthy controls (HC). Methodology: Plasma and saliva samples were collected from clinically and histopathologically confirmed cases of OL, OSMF and HC, with 12 participants in each group. The 8-isoprostane levels in all samples were analysed using the enzyme-linked immunosorbent assay (ELISA) technique. Results: The expression of 8-isoprostane level was statistically significant ( Conclusion: The study reveals a significant plasma and salivary 8-isoprostane level, where the concentration was higher in OPMD groups implying that saliva could be used as the diagnostic sample of choice for evaluating this oxidative stress marker.
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