Evidence map›Paper›PMID 41584657›Full record

ArticleJournal of oral and maxillofacial pathology : JOMFP

Histochemical analysis of mucin expression using mucicarmine and periodic acid-Schiff stains in pleomorphic adenoma and mucoepidermoid carcinoma: An unexplored niche in salivary gland tumour pathology.

Sankari P Kundu, Swapan K Purkait, Ananjan Chatterjee, Abhishek Banerjee, Sisca M Wati, Sumita Banerjee

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Article in Journal of oral and maxillofacial pathology : JOMFP. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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6 authors.

Sankari P KunduDepartment of Oral and Maxillofacial Pathology, Buddha Institute of Dental Sciences and Hospital, Patna, Bihar, India.
Swapan K PurkaitDepartment of Oral and Maxillofacial Pathology, Buddha Institute of Dental Sciences and Hospital, Patna, Bihar, India.
Ananjan ChatterjeeDepartment of Oral and Maxillofacial Pathology, Buddha Institute of Dental Sciences and Hospital, Patna, Bihar, India.
Abhishek BanerjeeDepartment of Oral and Maxillofacial Pathology, Awadh Dental College and Hospital, Jamshedpur, Jharkhand, India.
Sisca M WatiFaculty of Dental Medicine, Department of Oral and Maxillofacial Pathology, Universitas Airlangga, East Java, Indonesia.
Sumita BanerjeeDepartment of Oral Pathology, Dental College, Regional Institute of Medical Sciences, Imphal, Manipur, India.

Funding

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6 · The paper itself

Abstract

Background: Salivary glands, as exocrine glands, play a crucial role in saliva production, vital for maintaining oral cavity health and moisture. Histochemical analysis of saliva identifies mucins as its primary component. Variations in mucin characteristics could potentially indicate early neoplastic changes. Utilizing special stains such as PAS and mucicarmine is essential for accurately diagnosing salivary gland neoplasms (SGNs). This study focuses on the histochemical analysis of pleomorphic adenoma (PA) and mucoepidermoid carcinoma (MEC) to evaluate mucin expression using periodic acid-Schiff (PAS) and mucicarmine stains. Aim: To access, analyse and compare the mucin expression in cases of PA and MEC. Materials and Methods: The study group comprised 41 SGNs, which included 21 cases of MEC and 20 cases of PA, and 15 cases of normal oral mucosa containing minor salivary gland tissues were included in the control group. Histopathologically diagnosed cases, both PA and MEC, were selected, and tissue sections were stained with PAS and Mucicarmine to assess and analyse the mucin expression. Pearson's Chi-squared test was applied for the statistical analysis. Results and Conclusion: MEC stained with mucicarmine and PAS showed strong mucin expression in low-grade cases, moderate expression in intermediate-grade cases and weak mucin expression in high-grade cases, showing a statistically significant difference (

Indexed as

Histochemistrymucicarminemucoepidermoid carcinomaPASpleomorphic adenomasalivary glands

Identifiers

PMID41584657
PMCPMC12829605

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