ArticleJournal of oral and maxillofacial pathology : JOMFP
Immunoglobulin G (IgG) in oral submucous fibrosis and oral squamous cell carcinoma - An
Article in Journal of oral and maxillofacial pathology : JOMFP. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Context: Elevated IgG levels signify immune activation during the transition from OSMF to OSCC. Integrating IgG profiling with molecular diagnostics enhances early detection, risk prediction, and personalized treatment. Aims: The aim is to estimate and evaluate the serum immunoglobulin G (IgG) levels in OSMF and OSCC patients and compare them with the control group. Settings and Design: Sardar Patel Postgraduate Institute of Dental and Medical Sciences Cross-sectional, Observational, Quantitative Study. Methods and Materials: This study involved 36 participants aged 18 and older. After informed consent and oral examination, 2 mL blood samples were drawn, processed, and serum separated. Serum IgG levels were measured using Nephelometry (AGAPPE MISPA i2). Statistical analysis used: Statistical analysis was performed using the Chi-square test and ANOVA. Results: The mean serum IgG levels were highest in the OSCC group (1606.86 ± 500.44 mg/dL), followed by the OSMF group (1217.06 ± 136.95 mg/dL), and lowest in the control group (1113.58 ± 88.92 mg/dL). One-way ANOVA demonstrated a statistically significant difference in mean IgG levels among the three groups ( Conclusions: IgG levels were highest in OSCC, with a positive correlation to OSMF severity, suggesting its potential as a biomarker. Age, gender, and lifestyle factors significantly influenced disease onset and progression across the studied groups.
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