ArticleFrontiers in oncology2025
SERPINE1 maintained expression by NR4A1 promotes invasion and migration of glioblastoma in hypoxic microenvironment.
Article in Frontiers in oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Targeted Interference with USF2 Binding to the SERPINE1 Proximal Promoter E-Box in Dual Mutant p53Biomedicines · 2026Review
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9 authors.
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Abstract
Introduction: The activation of epithelial mesenchymal transition (EMT) characteristics in GBM cells is the main factor leading to this invasion and migration. Serpin family E member 1 (SERPINE1) encodes plasminogen activator inhibitor-1 (PAI-1), which plays a key role in regulating the extracellular matrix and is closely related to tumor progression and metastasis, especially in gliomas. However, the exact molecular mechanism of its role in GBM is still unclear. Methods: In this study, we evaluated the targeted therapeutic value of SERPINE1 through bioinformatics analysis. Study the effect of SERPINE1 inhibition on GBM cell proliferation and invasion using Results: Our research results indicate that GBM cells cultured in a low oxygen microenvironment have higher invasiveness, characterized by the activation of EMT markers. Inhibition of SERPINE1 Conclusion: This study provides new insights into the molecular mechanisms underlying the progression of GBM, emphasizing the role of SERPINE1 and its interaction with NR4A1 in promoting EMT and tumor invasion. Inhibiting the expression of SERPINE1 in GBM cells can prevent cell invasion, providing a potential strategy for the treatment of GBM.
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