ArticleFrontiers in oncology2025
Sex-divergent anatomic system concordance in second primary malignant neoplasms: a large-scale analysis.
Article in Frontiers in oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Expression of Estrogen Receptor Alpha and Ki-67 in Synchronous Canine Mammary Tumors.Journal of mammary gland biology and neoplasia · 2026Article
- Clinicopathological features and diagnostic intervals of second primary breast cancer following a prior malignancy: a single-center retrospective study.Frontiers in oncology · 2026Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: Using a second primary cancers (SPCs) database, this study aimed to analyze the epidemiological characteristics, systemic distribution, and correlation patterns of primary and SPCs across sexes. The goal was to identify potential sex-specific patterns and provide a reference for clinical prevention, diagnosis, and treatment. Methods: Clinical data of 918 patients with SPCs from two centers were retrospectively analyzed. Basic characteristics were summarized by sex. The systemic and specific type distributions of both primary and SPCs were analyzed. Association analyses explored cancer combination patterns and the tendency for subsequent cancers within the same system. Results: The cohort included 455 males (49.6%) and 463 females (50.4%), showing a balanced sex distribution (χ² = 0.143, Conclusion: This large-sample study systematically reveals sex-based differences in the characteristics and associative patterns of SPCs. This study systematically defines sex-specific, high-risk cancer-system profiles (e.g., digestive-to-digestive in males, respiratory-to-respiratory and reproductive-to-reproductive in females) and establishes 'anatomic system concordance' as a fundamental principle in the development of SPCs. These findings provide a robust foundation for sex-specific and primary cancer type-guided surveillance strategies. Future clinical practice can utilize these findings to develop stratified management plans based on patient sex and initial primary cancer type, aiming to reduce the incidence and mortality of multiple primary malignant neoplasms.
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