SynthesisFrontiers in oncology2025
Comparative efficacy of antibody-drug conjugates and chemotherapy for malignant tumors: a systematic review and meta-analysis.
Synthesis in Frontiers in oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Critical Quality Attribute Investigation and Analytical Method Establishment for Glyco-Site-Specific Anti-HER2 Bispecific ADC.Pharmaceuticals (Basel, Switzerland) · 2026Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Despite advancements in cancer treatment, malignant tumors remain a significant global health challenge. Drawbacks of chemotherapy, such as drug resistance and strong side effects, have prompted the exploration of antibody-drug conjugates (ADCs), which combine targeting capabilities with potent cytotoxins to enhance therapeutic efficacy. Methods: We searched PubMed, Cochrane, and EMBASE library databases up to June 8, 2025, for eligible randomized controlled trials (RCTs) and extracted relevant data. The primary outcome measures were overall survival (OS) and progression-free survival (PFS), with subgroup analysis and sensitivity analysis conducted to assess the heterogeneity of statistical results. Results: A total of thirteen RCTs involving 5,927 patients were included. The results indicated that ADCs offered superior OS (HR = 0.67, 95%CI: 0.55-0.81) and PFS (HR = 0.76; 95% CI: 0.66-0.86) compared to chemotherapy drugs. The any adverse event (96.8% vs. 93.6%), grade 3-5 adverse event (51.7% vs. 51.8%) and serious adverse event (25.3% vs. 22.4%) caused to patients were generally similar between ADCs and chemotherapy. Conclusion: Our meta-analysis demonstrates that compared to chemotherapy drugs, ADC drugs can prolong both OS and PFS in cancer patients, with no significant difference in adverse reactions. Systematic Review Registration: http://www.crd.york.ac.uk/PROSPERO, identifier CRD42024592020.
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