ArticleStroke (Hoboken, N.J.)2024
Prevalence of Systemic Hypertension and the Effects of Cerebral Revascularization in Patients With Moyamoya Disease.
Article in Stroke (Hoboken, N.J.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
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4 authors.
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Abstract
Background: Hypertension is often codiagnosed in patients with moyamoya disease (MMD), a progressive intracranial steno-occlusive vasculopathy; this has principally been attributed to renal artery stenosis (up to 10%). Susceptibility MMD genes, including ring finger protein 213/mysterin and Methods: Patients with MMD treated with extracranial-intracranial bypass from 2014 to 2018 were retrospectively enrolled. Blood pressure measurements and antihypertensive agent use were recorded pre- and postoperatively. Hypertension was defined according to the 2020 International Society of Hypertension Guidelines (adults) and 2017 American Academy of Pediatrics Guidelines (children). Multivariate logistic regression was performed for clinical and radiographic predictors of hypertension. Results: A total of 242 adult and 51 pediatric patients underwent revascularization. Preoperatively, 146 adult and 20 pediatric patients met the diagnostic criteria for hypertension resulting in prevalences of 60.3% and 39.2% respectively. In adults, this was significantly associated with age (odds ratio [OR] 1.05 [95% CI, 1.02-1.09]), body mass index (OR, 1.08 [95% CI, 1.03-1.13]), hyperlipidemia (OR, 2.57 [95% CI, 1.09-6.04]), kidney disease (OR, 18.98 [95% CI, 1.80-200.47]), and symptomatic presentation (OR, 8.88 [95% CI, 1.16-68.06]). After a mean follow-up of 34.3±18.1 months in adults (33.8±14.9 months - children), patients with hypertension decreased by 15.3% (1.9% - pediatrics) and 31.8% (17.7% - children) experienced improvement in hypertensive status with normalization of blood pressure or reduced need for antihypertensive agents. Posterior circulation involvement was a negative predictor for response of hypertensive status to revascularization (OR, 0.10 [95% CI, 0.01-0.79]). Conclusion: Hypertension is prevalent among adult and pediatric patients with MMD with contributions from known vascular risk factors. Its association with symptomatic presentation and observed improvement following revascularization suggests blood pressure changes, in part, are a compensatory physiological response to increased intracranial vascular resistance.
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