ArticleCurrent health sciences journal
High Prevalence of Multidrug- Resistant Klebsiella Pneumoniae in Pediatric Patients: A Retrospective Analysis.
Article in Current health sciences journal. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Biofilm-Mediated Antimicrobial Resistance in PediatricAntibiotics (Basel, Switzerland) · 2026Review
- Antimicrobial Resistance Profile ofAntibiotics (Basel, Switzerland) · 2026Article
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Antibiotic-resistant infections in children are a growing clinical concern worldwide. Klebsiella pneumoniae (K.pneumoniae) is a leading cause of hospital-acquired infections and often exhibits multidrug resistance, including extended-spectrum β-lactamase (ESBL) production and carbapenem resistance. This study examines the prevalence of K. pneumoniae in pediatric patients upon hospital admission and characterizes its antibiotic resistance profile.
objectivesThis study aimed to determine its prevalence and resistance patterns in children at hospital admission.
methodsWe conducted a retrospective study of 93 pediatric inpatients admitted to a tertiary children's hospital. Clinical and microbiology records were reviewed to identify patients with K. pneumoniae isolated from admission cultures. Antibiotic susceptibility testing was performed on each K. pneumoniae isolate for a panel of antibiotics spanning penicillins, cephalosporins, carbapenems, aminoglycosides, tetracyclines, and fluoroquinolones. The frequencies of resistance and sensitivity were determined for each antibiotic. Fisher's exact tests and factorial ANOVA were used to assess associations between patient diagnosis and resistance.
resultsOut of 93 pediatric patients, 18 (19.35%) had K. pneumoniae isolated, with 72.2% of strains classified as multidrug-resistant. Resistance was highest to ceftriaxone (50%) and ampicillin (44%). Carbapenems and amikacin remained largely effective.
conclusionNearly one-fifth of children admitted had K. pneumoniae detected on initial cultures, with a majority of these isolates exhibiting multidrug resistance, especially to common cephalosporins and penicillins. The high rate of ceftriaxone resistance suggests a prevalence of ESBL-producing strains. Carbapenems and amikacin remained largely effective, underscoring their importance as empiric or targeted therapies in severe pediatric infections.
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