ArticleNeurophotonics2026
Cellular-resolution OCT reveals layer-specific retinal mosaics and ganglion cell degeneration in mouse retina
Article in Neurophotonics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Ultrabroadband OCT for simultaneous visible and near-infrared light imaging of the mouse retina.Biomedical optics express · 2026Article
- Evaluating the Optic Nerve Crush Model to Understand the Function of Microglia in Glaucoma Neuroprotection.Investigative ophthalmology & visual science · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Significance: Cellular-resolution retinal imaging in mouse models is hindered by optical aberrations and speckle noise, limiting the ability to visualize and track individual cells Aim: We developed a wavefront sensorless adaptive optics optical coherence tomography (WSAO-OCT) platform designed to achieve reliable cellular-level imaging of the mouse retina. Approach: The system integrates real-time aberration correction with multivolume averaging to simultaneously improve image quality and suppress speckle noise. Imaging results were validated using immunohistochemistry, and the platform was applied to monitor retinal ganglion cell (RGC) degeneration following optic nerve injury. Results: WSAO-OCT improved image contrast by 61% and sharpness by 55%, whereas averaging 50 volumes markedly reduced speckle noise. The system enabled visualization of individual cells across all retinal layers and the retinal pigment epithelium. Immunohistochemistry confirmed that 95% of optically detected cells in the RGC layer corresponded to true RGCs. Following optic nerve injury, Conclusions: WSAO-OCT provides a noninvasive, quantitative, and cell-specific imaging tool for preclinical retinal research, offering translational potential for longitudinal monitoring and therapeutic evaluation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.