ArticleFrontiers in cardiovascular medicine2025
Recurrent coronary artery in-stent restenosis caused by metal allergy: a case report.
Article in Frontiers in cardiovascular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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6 authors.
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Abstract
This article describes the case of a middle-aged woman who developed recurrent in-stent restenosis (ISR) due to metal allergy. The first ISR occurred after implantation of a nickel-rich Medtronic Endeavor Resolute stent (35% nickel, 35% cobalt, and 20% chromium). A skin patch test revealed a strong nickel allergy (++), with no allergic reaction to cobalt. Nickel allergy was considered to be the cause of the first ISR. Then, a drug-coated balloon platinum-chromium alloy stent was implanted, and ISR occurred again during follow-up. The article discusses this special case and clinically relevant management options. This case highlights a scenario with refractory in-stent restenosis persisting despite various treatment strategies, including stents with different metal components, drug-coated balloons, and intensive drug therapy.
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