ReviewFrontiers in cardiovascular medicine2025
Prognostic value of neutrophil to lymphocyte ratio in patients with aortic dissection: a systematic review and meta-analysis.
Review in Frontiers in cardiovascular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed.
- Preoperative inflammatory indicators predict postoperative SIRS after cardiac surgery with cardiopulmonary bypass in older patients.BMC geriatrics · 2026Article
- Risk factors and prognostic analysis of acute kidney injury after Sun's procedure for acute Stanford type A aortic dissection.Journal of thoracic disease · 2026Article
- NETosis Markers (ssDNA, dsDNA) as Predictors of Mortality and Hospitalization After Endovascular Aortic Repair.International journal of molecular sciences · 2026Article
- Predictive value of preoperative neutrophil-to-lymphocyte ratio for prognosis in aortic dissection patients without hypertension following TEVAR.Frontiers in aging · 2026Article
- Thrombo-inflammation as a missing variable in thoracic aortic intervention timing: toward a biology-informed threshold.Frontiers in cardiovascular medicine · 2026Review
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Aortic dissection (AD) is a highly fatal cardiovascular condition, with mortality exceeding 50% within the first 24 h and postoperative mortality approaching 30%. Inflammatory mechanisms have been implicated in AD pathogenesis, but the prognostic value of the neutrophil-to-lymphocyte ratio (NLR) remains uncertain. This study aimed to synthesize available evidence on NLR as a predictor of adverse outcomes in AD and to inform hypotheses for future research. Methods: Following PRISMA 2020 guidance, a systematic search was conducted in Web of Science, PubMed, Embase, and the Cochrane Library through December 2024. Study selection, data extraction, and quality assessment were performed independently by two reviewers. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using a random-effects model. Heterogeneity and potential bias were evaluated via subgroup analyses, sensitivity testing, and Egger's regression. Results: Eleven studies (12 comparative groups) comprising 1,792 patients were included (one publication reported two independent cohorts). Eelevated NLR was associated with increased mortality risk (pooled OR = 1.16, 95% CI: 1.05-1.27, Conclusion: The evidence indicates that elevated NLR may serve as a potential independent predictor of mortality in AD, supporting its incorporation into risk stratification frameworks. Notwithstanding substantial publication bias-predominantly among smaller studies-sensitivity analyses confirmed the overall result stability. The observed prognostic value aligns with NLR's role in other vascular diseases, consistent with its interpretation as a marker of inflammatory burden. Generalizability is limited by the predominance of small Asian cohorts; therefore, multicenter prospective studies are required to validate these findings and to establish optimal NLR thresholds for individualized management. Systematic Review Registration: https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=648318, PROSPERO CRD42025648318.
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